For a decade, as transplant physicians harvested organs, Dr Shamsuddin collected healthy intestinal tissue for research.
He compared this truly healthy tissue from organ donors, with similar looking and supposedly "healthy" tissue found away from tumors obtained from colon cancer patients.
Professor Shamsuddin discusses the cancer screening tests
Truly healthy tissue from organ donors looked the same as non-cancerous tissue in the colon. However, only tumors and precancerous tissue produced mucus with an altered sugar.
The Professor felt that the altered sugar molecule could be used as a marker. His research was featured on the cover of the JNCI.
The test was indeed able to distinguish healthy tissue that did not produce the altered sugar, from tumors and precancerous tissue at a high risk of developing into a tumor.
Early detection screening was now a reality!
Clinical trials take a lot of time and a lot of money. Each trial requires time for planning, grant proposals, various approvals, recruiting of patients, review of data, publishing of papers etc.
Thank you to researchers from several countries who helped to validate the high accuracy of these screening tests.
We would also like to thank the thousands of patients that took part in the numerous clinical trials- you helped make these tests a reality!